isobole.Rd'isobole' displays isobole based on EC/ED50 estimates from a log-logistic model. Additionally isoboles determined by the concentration addition model, Hewlett's model and Voelund's model can be added to the plot.
isobole(object1, object2, exchange = 1, cifactor = 2, ename = "e", xaxis = "100", xlab, ylab, xlim, ylim, ...)
| object1 | object of class 'drc' where EC/ED50 parameters vary freely. |
|---|---|
| object2 | object of class 'drc' where EC/ED50 parameters vary according to Hewlett's model. |
| ename | character string. The name of the EC/ED50 variable. |
| xaxis | character string. Is the mixture "0:100" or "100:0" on the x axis? |
| exchange | numeric. The exchange rate between the two substances. |
| cifactor | numeric. The factor to be used in the confidence intervals. Default is 2, but 1 has been used in publications. |
| xlab | an optional label for the x axis. |
| ylab | an optional label for the y axis. |
| xlim | a numeric vector of length two, containing the lower and upper limit for the x axis. |
| ylim | a numeric vector of length two, containing the lower and upper limit for the y axis. |
| … | Additional graphical parameters. |
The model fits to be supplied as first and optionally second argument are obtained
using mixture and drm.
No value is returned. Only used for the side effect: the isobologram shown.
Ritz, C. and Streibig, J. C. (2014) From additivity to synergism - A modelling perspective Synergy, 1, 22--29.